Targeting anti-apoptotic BCL-2 family proteins for cancer treatment

Future Med Chem. 2020 Apr;12(7):563-565. doi: 10.4155/fmc-2020-0004. Epub 2020 Feb 21.

Authors

Xuan Zhang¹, Xingui Liu², Daohong Zhou², Guangrong Zheng¹

Affiliations

¹ Department of Medicinal Chemistry, College of Pharmacy, University of Florida, 1333 Center Drive, Gainesville, FL 32610, USA.
² Department of Pharmacodynamics, College of Pharmacy, University of Florida, 1333 Center Drive, Gainesville, FL 32610, USA.

PMID: 32083493
DOI: 10.4155/fmc-2020-0004

No abstract available

Keywords: BCL-2; BCL-XL; MCL-1; apoptosis; cancer treatment.

Publication types

Editorial
Research Support, N.I.H., Extramural

MeSH terms

Antineoplastic Agents / pharmacology*
Apoptosis Regulatory Proteins / antagonists & inhibitors*
Apoptosis Regulatory Proteins / metabolism
Humans
Neoplasms / drug therapy*
Neoplasms / metabolism
Neoplasms / pathology
Proto-Oncogene Proteins c-bcl-2 / antagonists & inhibitors*
Proto-Oncogene Proteins c-bcl-2 / metabolism

Substances

Antineoplastic Agents
Apoptosis Regulatory Proteins
Proto-Oncogene Proteins c-bcl-2

Grants and funding