Insights Into the Role of Endoplasmic Reticulum Stress in Infectious Diseases

Ji-Ae Choi; Chang-Hwa Song

doi:10.3389/fimmu.2019.03147

Insights Into the Role of Endoplasmic Reticulum Stress in Infectious Diseases

Front Immunol. 2020 Jan 31:10:3147. doi: 10.3389/fimmu.2019.03147. eCollection 2019.

Authors

Ji-Ae Choi^{1

2

3}, Chang-Hwa Song^{1

2

3}

Affiliations

¹ Department of Medical Science, College of Medicine, Chungnam National University, Daejeon, South Korea.
² Department of Microbiology, College of Medicine, Chungnam National University, Daejeon, South Korea.
³ Research Institute for Medical Sciences, College of Medicine, Chungnam National University, Daejeon, South Korea.

Abstract

The endoplasmic reticulum (ER) is the major organelle in the cell for protein folding and plays an important role in cellular functions. The unfolded protein response (UPR) is activated in response to misfolded or unfolded protein accumulation in the ER. However, the UPR successfully alleviates the ER stress. If UPR fails to restore ER homeostasis, apoptosis is induced. ER stress plays an important role in innate immune signaling in response to microorganisms. Dysregulation of UPR signaling contributes to the pathogenesis of a variety of infectious diseases. In this review, we summarize the contribution of ER stress to the innate immune response to invading microorganisms and its role in the pathogenesis of infectious diseases.

Keywords: ER stress; UPR (unfolded protein response); apoptosis; bacteria; infection; infectious disease; pathogen; viruses.

Publication types

Research Support, Non-U.S. Gov't
Review

MeSH terms

Animals
Endoplasmic Reticulum Stress / immunology*
Humans
Immunity, Innate / immunology*
Infections / immunology*
Unfolded Protein Response / immunology*