Macrophage-HFE controls iron metabolism and immune responses in aged mice

Naveen Kumar Tangudu; Dilay Yilmaz; Katharina Wörle; Andreas Gruber; Silvia Colucci; Kerstin Leopold; Martina U Muckenthaler; Maja Vujic Spasic

doi:10.3324/haematol.2019.235630

Macrophage-HFE controls iron metabolism and immune responses in aged mice

Haematologica. 2021 Jan 1;106(1):259-263. doi: 10.3324/haematol.2019.235630.

Authors

Naveen Kumar Tangudu¹, Dilay Yilmaz¹, Katharina Wörle², Andreas Gruber³, Silvia Colucci⁴, Kerstin Leopold³, Martina U Muckenthaler⁴, Maja Vujic Spasic¹

Affiliations

¹ Institute of Comparative Molecular Endocrinology, Ulm University, Ulm.
² Institute of Analytical and Bioanalytical Chemistry, Ulm University, Ulm, Germany.
³ Institute of Analytical and Bioanalytical Chemistry, Ulm University, Ulm.
⁴ Department of Pediatric Hematology, Oncology and Immunology - University of Heidelberg, Heidelberg.

No abstract available

Publication types

Letter
Research Support, Non-U.S. Gov't

MeSH terms

Animals
Hemochromatosis Protein
Hemochromatosis*
Immunity
Iron / metabolism*
Liver
Macrophages / metabolism*
Mice
Mice, Knockout

Substances

Hemochromatosis Protein
Hfe protein, mouse
Iron

Grants and funding

Funding: This work was supported by the German Research Foundation (DFG, VU75/2-1) and by Ulm University (support for MVS). MUM acknowledges funding from the DFG (SFB1036) and support from the late Dr. Andre Bachmann, who strongly believed in a beneficial role of the C282Y genotype.