Implementation and Validation of a Three-dimensional Cardiac Motion Estimation Network

Manuel A Morales; David Izquierdo-Garcia; Iman Aganj; Jayashree Kalpathy-Cramer; Bruce R Rosen; Ciprian Catana

doi:10.1148/ryai.2019180080

Implementation and Validation of a Three-dimensional Cardiac Motion Estimation Network

Radiol Artif Intell. 2019 Jul 17;1(4):e180080. doi: 10.1148/ryai.2019180080.

Authors

Manuel A Morales¹, David Izquierdo-Garcia¹, Iman Aganj¹, Jayashree Kalpathy-Cramer¹, Bruce R Rosen¹, Ciprian Catana¹

Affiliation

¹ Athinoula A. Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital and Harvard Medical School, 149 13th St, Charlestown, MA 02129 (M.A.M., D.I.G., I.A., J.K.C., B.R.R., C.C.); Harvard-MIT Division of Health Sciences and Technology (M.A.M.) and Computer Science and Artificial Intelligence Laboratory (I.A.), Massachusetts Institute of Technology, Cambridge, Mass.

Abstract

Purpose: To describe an unsupervised three-dimensional cardiac motion estimation network (CarMEN) for deformable motion estimation from two-dimensional cine MR images.

Materials and methods: A function was implemented using CarMEN, a convolutional neural network that takes two three-dimensional input volumes and outputs a motion field. A smoothness constraint was imposed on the field by regularizing the Frobenius norm of its Jacobian matrix. CarMEN was trained and tested with data from 150 cardiac patients who underwent MRI examinations and was validated on synthetic (n = 100) and pediatric (n = 33) datasets. CarMEN was compared to five state-of-the-art nonrigid body registration methods by using several performance metrics, including Dice similarity coefficient (DSC) and end-point error.

Results: On the synthetic dataset, CarMEN achieved a median DSC of 0.85, which was higher than all five methods (minimum-maximum median [or MMM], 0.67-0.84; P < .001), and a median end-point error of 1.7, which was lower than (MMM, 2.1-2.7; P < .001) or similar to (MMM, 1.6-1.7; P > .05) all other techniques. On the real datasets, CarMEN achieved a median DSC of 0.73 for Automated Cardiac Diagnosis Challenge data, which was higher than (MMM, 0.33; P < .0001) or similar to (MMM, 0.72-0.75; P > .05) all other methods, and a median DSC of 0.77 for pediatric data, which was higher than (MMM, 0.71-0.76; P < .0001) or similar to (MMM, 0.77-0.78; P > .05) all other methods. All P values were derived from pairwise testing. For all other metrics, CarMEN achieved better accuracy on all datasets than all other techniques except for one, which had the worst motion estimation accuracy.

Conclusion: The proposed deep learning-based approach for three-dimensional cardiac motion estimation allowed the derivation of a motion model that balances motion characterization and image registration accuracy and achieved motion estimation accuracy comparable to or better than that of several state-of-the-art image registration algorithms.© RSNA, 2019Supplemental material is available for this article.

2019 by the Radiological Society of North America, Inc.

Abstract

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