SF3B1 mutations induce R-loop accumulation and DNA damage in MDS and leukemia cells with therapeutic implications

Affiliations

• ¹ Bloodwise Molecular Haematology Unit, Nuffield Division of Clinical Laboratory Sciences, Radcliffe Department of Medicine, University of Oxford, Oxford, UK.
• ² Clinical Pathology Department, Assiut University, Assiut, Egypt.
• ³ Weatherall Institute of Molecular Medicine, Radcliffe Department of Medicine, University of Oxford, Oxford, UK.
• ⁴ Oxford Medical Genetics Laboratories, Oxford University Hospitals NHS Foundation Trust, The Churchill Hospital, Oxford, UK.
• ⁵ Centre for Genomic and Experimental Medicine, MRC Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh, UK.
• ⁶ Stem Cell Research, Nuffield Division of Clinical Laboratory Sciences, Radcliffe Department of Medicine, University of Oxford, Oxford, UK.
• ⁷ National Health Service Blood and Transplant, John Radcliffe Hospital, Oxford, UK.
• ⁸ Molecular Diagnostic Centre, Department of Oncology, University of Oxford, Oxford, UK.
• ⁹ MRC Molecular Hematology Unit, WIMM, University of Oxford, Oxford, UK.
• ¹⁰ Haematology Theme Oxford Biomedical Research Centre and Department of Hematology, Oxford University Hospitals NHS Foundation Trust, Oxford, UK.
• ¹¹ Department of Haematology, Royal Bournemouth Hospital, Bournemouth, UK.
• ¹² Department of Oncological Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
• ¹³ Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
• ¹⁴ Black Family Stem Cell Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
• ¹⁵ Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
• ¹⁶ Division of Cancer Sciences, University of Manchester, Manchester, UK.
• ¹⁷ Bloodwise Molecular Haematology Unit, Nuffield Division of Clinical Laboratory Sciences, Radcliffe Department of Medicine, University of Oxford, Oxford, UK. andrea.pellagatti@ndcls.ox.ac.uk.
• ¹⁸ Bloodwise Molecular Haematology Unit, Nuffield Division of Clinical Laboratory Sciences, Radcliffe Department of Medicine, University of Oxford, Oxford, UK. jacqueline.boultwood@ndcls.ox.ac.uk.