In Situ Support of ILC Precursors

Lei Zhou; Gregory F Sonnenberg

doi:10.1016/j.immuni.2020.01.011

In Situ Support of ILC Precursors

Immunity. 2020 Feb 18;52(2):207-209. doi: 10.1016/j.immuni.2020.01.011.

Authors

Lei Zhou¹, Gregory F Sonnenberg²

Affiliations

¹ Joan and Sanford I. Weill Department of Medicine, Division of Gastroenterology, Weill Cornell Medicine, Cornell University, New York, NY, USA; Department of Microbiology and Immunology, Weill Cornell Medicine, Cornell University, New York, NY, USA; Jill Roberts Institute for Research in Inflammatory Bowel Disease, Weill Cornell Medicine, Cornell University, New York, NY, USA.
² Joan and Sanford I. Weill Department of Medicine, Division of Gastroenterology, Weill Cornell Medicine, Cornell University, New York, NY, USA; Department of Microbiology and Immunology, Weill Cornell Medicine, Cornell University, New York, NY, USA; Jill Roberts Institute for Research in Inflammatory Bowel Disease, Weill Cornell Medicine, Cornell University, New York, NY, USA. Electronic address: gfsonnenberg@med.cornell.edu.

PMID: 32075721
DOI: 10.1016/j.immuni.2020.01.011

Abstract

Innate lymphoid cells (ILCs) are tissue-resident lymphocytes that promote immunity to pathogens at mucosal barriers, but the mechanisms regulating their development within tissues remain poorly understood. In this issue of Immunity, Oherle et al. identify a niche in the neonatal airway where stromal cell-derived insulin-like growth factor 1 (IGF1) supports the proliferation of ILC precursors and protects from infection.

Publication types

Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Comment

MeSH terms

Humans
Immunity, Innate*
Infant, Newborn
Insulin-Like Growth Factor I
Lung
Lymphocytes*

Substances

Insulin-Like Growth Factor I

Abstract

Publication types

MeSH terms

Substances

Grants and funding