Abstract
An architectural polymer containing hydrophobic isoxazole-based dendron and hydrophilic polyethylene glycol linear tail is prepared by a combination of the robust ZnCl2 catalyzed alkyne-nitrile oxide 1,3-dipolar cycloaddition and esterification chemistry. This water soluble amphiphilic telodendrimer acts as a macromolecular biologically active agent and shows concentration dependent reduction of glioblastoma (U251) cell survival.
Keywords:
1,3-dipolar cycloaddition; glioblastoma; macromolecular drug; telodendrimer.
MeSH terms
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Alkynes / chemistry
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Antineoplastic Agents / chemical synthesis*
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Antineoplastic Agents / pharmacology
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Catalysis
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Cell Line, Tumor
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Cell Survival / drug effects
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Chlorides / chemistry
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Cycloaddition Reaction
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Dendrimers / chemical synthesis*
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Dendrimers / pharmacology
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Dose-Response Relationship, Drug
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Drug Design
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Humans
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Hydrophobic and Hydrophilic Interactions
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Isoxazoles / chemical synthesis*
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Isoxazoles / pharmacology
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Neuroglia / drug effects*
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Neuroglia / pathology
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Nitriles / chemistry
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Oxides / chemistry
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Polyethylene Glycols / chemistry*
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Solubility
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Water / chemistry
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Zinc Compounds / chemistry
Substances
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Alkynes
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Antineoplastic Agents
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Chlorides
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Dendrimers
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Isoxazoles
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Nitriles
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Oxides
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Zinc Compounds
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Water
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Polyethylene Glycols
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zinc chloride