Abstract
We report on the first high-level azithromycin-resistant Neisseria gonorrhoeae isolate (minimum inhibitory concentration, ≥256 μg/mL) in North Carolina isolated from a pharyngeal swab of a 33-year-old HIV-negative man who has sex with men. In addition, the isolate was found to be susceptible to cefixime, ceftriaxone, and penicillin and resistant to tetracycline. By whole-genome sequencing, the strain was assigned as MLST ST9363, NG-MAST ST5035, and a novel NG-STAR sequence type, ST1993.
Publication types
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Case Reports
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Adult
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Anti-Bacterial Agents / pharmacology*
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Anti-Bacterial Agents / therapeutic use
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Azithromycin / pharmacology*
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Azithromycin / therapeutic use
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Cefixime / pharmacology
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Cefixime / therapeutic use
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Ceftriaxone / pharmacology
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Ceftriaxone / therapeutic use
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Drug Resistance, Bacterial / drug effects
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Drug Resistance, Bacterial / genetics
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Gonorrhea / drug therapy*
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HIV Seronegativity
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Homosexuality, Male
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Humans
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Male
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Microbial Sensitivity Tests
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Multilocus Sequence Typing
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Neisseria gonorrhoeae / drug effects*
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Neisseria gonorrhoeae / genetics
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North Carolina / epidemiology
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Penicillins / pharmacology
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Penicillins / therapeutic use
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Pharynx / microbiology
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Tetracycline / pharmacology
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Tetracycline / therapeutic use
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Whole Genome Sequencing
Substances
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Anti-Bacterial Agents
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Penicillins
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Ceftriaxone
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Azithromycin
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Cefixime
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Tetracycline