1 From the University of Cologne, Faculty of Medicine, and University Hospital of Cologne, Department of Anaesthesiology and Intensive Care Medicine, Germany (RS), Department of Perioperative Medicine and Critical Care, University Hospital Southampton NHS Trust, United Kingdom (DL), Department of Anaesthesia, Peri-operative and Pain Medicine, Peter MacCallum Cancer Centre and the Centre for Integrated Critical Care and The Sir Peter MacCallum Department of Oncology, University of Melbourne, Australia (BR).