Click-tambjamines as efficient and tunable bioactive anion transporters

Chem Commun (Camb). 2020 Mar 12;56(21):3218-3221. doi: 10.1039/d0cc00643b.

Abstract

A novel class of transmembrane anion carriers, the click-tambjamines, display remarkable anionophoric activities in model liposomes and living cells. The versatility of this building block for the generation of molecular diversity offers promise to develop future drugs based on this design.

MeSH terms

  • A549 Cells
  • Anions / chemical synthesis
  • Anions / chemistry
  • Anions / pharmacology
  • Antineoplastic Agents / chemical synthesis
  • Antineoplastic Agents / chemistry
  • Antineoplastic Agents / pharmacology*
  • Cell Line
  • Cell Proliferation / drug effects
  • Crystallography, X-Ray
  • Dose-Response Relationship, Drug
  • Drug Screening Assays, Antitumor
  • Humans
  • Ion Transport
  • Liposomes / chemistry
  • MCF-7 Cells
  • Models, Molecular
  • Molecular Structure
  • Pyrroles / chemical synthesis
  • Pyrroles / chemistry
  • Pyrroles / pharmacology*
  • Structure-Activity Relationship

Substances

  • Anions
  • Antineoplastic Agents
  • Liposomes
  • Pyrroles