Sequencing data of cell-free DNA fragments in living-related liver transplantation for inborn errors of metabolism

Xiaofan Zhu; Hoi Ioi Ng; Liming Xuan; Yan Long; Yan Mao; Yu Shi; Liying Sun; Bo Liang; Fernando Scaglia; Zhijun Zhu; Kwong Wai Choy

doi:10.1016/j.dib.2020.105183

Sequencing data of cell-free DNA fragments in living-related liver transplantation for inborn errors of metabolism

Data Brief. 2020 Jan 25:29:105183. doi: 10.1016/j.dib.2020.105183. eCollection 2020 Apr.

Authors

Xiaofan Zhu¹, Hoi Ioi Ng², Liming Xuan³, Yan Long², Yan Mao³, Yu Shi², Liying Sun², Bo Liang^{3

4}, Fernando Scaglia^{5

6

7}, Zhijun Zhu², Kwong Wai Choy^{1

7}

Affiliations

¹ Department of Obstetrics and Gynaecology, The Chinese University of Hong Kong, Hong Kong, China.
² Liver Transplantation Center, National Clinical Research Center for Digestive Diseases, Beijing Friendship Hospital, Capital Medical University, Beijing, 100050, China.
³ Basecare Medical Device Co., Ltd., 218 Xinghu Road, SIP, Suzhou, Jiangsu, 215001, China.
⁴ State Key Laboratory of Microbial Metabolism, Joint International Research Laboratory of Metabolic and Developmental Sciences, School of Life Sciences and Biotechnology, Shanghai Jiao Tong University, Shanghai, 200240, China.
⁵ Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX, USA.
⁶ Texas Children's Hospital, Houston, TX, USA.
⁷ The Chinese University of Hong Kong-Baylor College of Medicine Joint Center for Medical Genetics, Hong Kong, China.

Abstract

Graft derived cell-free DNA was recently reported as a non-invasive biomarker to detect graft damage or rejection after liver transplantation. There are a number of methods for quantification of Gcf-DNA, including quantitative-PCR, digital droplet PCR and massively parallel sequencing (next generation sequencing). Here we present the NGS data and fragment size distribution of cell-free DNA in the plasma of patients with inborn errors of metabolism who underwent living-related liver transplantation. For more insights please see Analysis of fragment size distribution of cell-free DNA: a potential noninvasive marker to monitor graft damage in living-related liver transplantation for inborn errors of metabolism. [1].

Keywords: Fragment size; Graft derived cell-free DNA; Inborn errors of metabolism; Living-related liver transplantation.