Synthesis of carbon-dots@SiO2@TiO2 nanoplatform for photothermal imaging induced multimodal synergistic antitumor

Bing Wei; Fei Dong; Wei Yang; Chunhua Luo; Qiujing Dong; Zuoqin Zhou; Zheng Yang; Liangquan Sheng

doi:10.1016/j.jare.2020.01.011

Synthesis of carbon-dots@SiO₂@TiO₂ nanoplatform for photothermal imaging induced multimodal synergistic antitumor

J Adv Res. 2020 Jan 25:23:13-23. doi: 10.1016/j.jare.2020.01.011. eCollection 2020 May.

Authors

Bing Wei¹, Fei Dong¹, Wei Yang², Chunhua Luo¹, Qiujing Dong¹, Zuoqin Zhou¹, Zheng Yang^{1

3}, Liangquan Sheng¹

Affiliations

¹ School of Chemistry and Materials Engineering, Engineering Research Center of Biomass Conversion and Pollution Prevention of Anhui Educational Institutions, Fuyang Normal University, Fuyang 236037, PR China.
² Anhui Chemical Engineering School, Anqing 246300, PR China.
³ AnHui Province Key Laboratory of Chemistry for Inorganic/Organic Hybrid Functionalized Materials, Anhui University, Hefei 230601, PR China.

Abstract

For facilitating theranostic nanoplatform with multimodal therapeutic ability, we develop the core-shell structured CDs@SiO₂@TiO₂ nanoplatforms (CST NPs). The designed CST NPs possess excellent photothermal effect and fluorescence resonance energy transfer (FRET) induced photodynamic property, which could achieve synergistic photothermal and photodynamic therapy. Meanwhile, the photothermal ability of CST NPs acts as a key role in the application of real-time photothermal imaging, benefitting for the diagnosis of tumor accurately. Moreover, the obtained CST NPs also exhibit outstanding sonodynamic effect with huge potential for sonodynamic therapy. Under the 650 nm laser irradiation, the synthesized CST NPs not only inhibit the growth of cancer cells in vitro, but also display precise photothermal imaging and photo-induced ablation to tumor in vivo. As a result, the prepared CST NPs may potentially serve as multifunctional nanoplatform for theranostic antitumor and pave the avenue for clinic cancer therapy.

Keywords: Multimodal synergistic antitumor; Photodynamic therapy; Photothermal imaging; Photothermal therapy; Sonodynamic effect.