Treating hand and foot osteoarthritis using a patient's own blood: A systematic review and meta-analysis of platelet-rich plasma

Adam Evans; Maryo Ibrahim; Rand Pope; James Mwangi; Mina Botros; Shepard P Johnson; Salam Al Kassis

doi:10.1016/j.jor.2020.01.037

Treating hand and foot osteoarthritis using a patient's own blood: A systematic review and meta-analysis of platelet-rich plasma

J Orthop. 2020 Jan 28:18:226-236. doi: 10.1016/j.jor.2020.01.037. eCollection 2020 Mar-Apr.

Authors

Adam Evans¹, Maryo Ibrahim¹, Rand Pope², James Mwangi¹, Mina Botros¹, Shepard P Johnson³, Salam Al Kassis³

Affiliations

¹ Meharry Medical College, 1005 Dr DB Todd Jr Blvd, Nashville, TN, 37208, USA.
² Vanderbilt University School of Medicine, 1161 21st Ave South, Nashville, TN, 37232, USA.
³ Vanderbilt University Medical Center Department of Plastic Surgery, D-4207 Medical Center North, 1211 Medical Center Drive, Nashville, TN, 37212, USA.

Abstract

Background: This study summarizes all literature investigating platelet-rich plasma (PRP) in the treatment of osteoarthritis of the hands and feet.

Materials & methods: This is a PRISMA compliant systematic review of 7 databases and includes a meta-analysis of randomized controlled trial (RCT) data on pain and function.

Results: Nine articles were included in the review. Meta-analysis of 4 RCTs shows PRP significantly improves pain and function versus control. More results are significant at longer duration follow-up.

Conclusions: PRP improves pain and function of osteoarthritis. Heterogeneity and risk-of-bias limit current data, requiring more RCTs to determine any regenerative potential of PRP.

Prospero systematic review registration number: 136582.

Keywords: Ankle; Cartilage; Foot; Hand; Intra-articular injections; Osteoarthritis; Platelet-rich plasma.

Publication types

Review