A Novel Controllable Pneumatic Needle-Free Injection System for Larger-Volume Drug Delivery

Dongping Zeng; Ni Wu; Lei Qian; Hanqing Shi; Yong Kang

doi:10.1016/j.xphs.2020.02.003

A Novel Controllable Pneumatic Needle-Free Injection System for Larger-Volume Drug Delivery

J Pharm Sci. 2020 May;109(5):1772-1779. doi: 10.1016/j.xphs.2020.02.003. Epub 2020 Feb 15.

Authors

Dongping Zeng¹, Ni Wu¹, Lei Qian¹, Hanqing Shi¹, Yong Kang²

Affiliations

¹ School of Power and Mechanical Engineering, Wuhan University, Wuhan 430072, China; Hubei Key Laboratory of Accoutrement Technique in Fluid Machinery and Power Engineering, Wuhan University, Wuhan 430072, China; Hubei Key Laboratory of Waterjet Theory and New Technology, Wuhan University, Wuhan 430072, China.
² School of Power and Mechanical Engineering, Wuhan University, Wuhan 430072, China; Hubei Key Laboratory of Accoutrement Technique in Fluid Machinery and Power Engineering, Wuhan University, Wuhan 430072, China; Hubei Key Laboratory of Waterjet Theory and New Technology, Wuhan University, Wuhan 430072, China. Electronic address: kangyong@whu.edu.cn.

PMID: 32070699
DOI: 10.1016/j.xphs.2020.02.003

Abstract

Hypodermic needles and syringes are currently the main route of the transdermal administration. Many complaints associated with needle-stick injuries, needle phobia, and needle abuse have motivated the development of alternative drug delivery strategies. Pneumatic needle-free injections stand out from various alternative strategies because of the convenience in adjusting the driving pressure and the injection volume. This study proposed a novel control method of the pneumatic needle-free injection for delivering larger volume drugs to the target sites at desired rates and time by controlling the driving pressure. The dynamic characteristics of this injection mode were evaluated in the impact experiments and the results confirmed the reliability of this controllable system in controlling the outlet pressure and jet velocity. The injection performances of it were compared with that of other injection modes through in vivo and in vitro experiments. This controllable system was able to control the injection depth and it was more conducive to the lateral diffusion of the liquid jets in gelatin. Moreover, it could not only enlarge the diffusion of diclofenac solution in rats, but also accelerate the metabolism of diclofenac solution in rats. All experimental results confirmed the reliability of this controllable injection system.

Keywords: circuit controller; controllable device; diclofenac sodium; drug delivery; needle-free injection.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Animals
Drug Delivery Systems
Equipment Design
Injections, Jet
Needles
Pharmaceutical Preparations*
Rats
Reproducibility of Results
Skin*

Substances

Pharmaceutical Preparations