Innovators in atherosclerosis research: A historical review

Abstract

This review presents a retrospective analysis of the significance of the contributions of pathologists and kindred investigators in the latter half of the twentieth century to the advancement of understanding of atherosclerosis, a major disease and affliction of humankind. These outstanding investigators contributed importantly to the development of a large body of evidence encompassing population-based autopsy studies, experimental animal studies and cell biological investigations that, coupled with insights from epidemiological studies, serve as the underpinning for the current dominant response to injury theory of atherogenesis. Their collective contributions have been highly meritorious and will remain seminally important into the future.

Keywords: Atherosclerosis; Cardiovascular pathology; Pathology; Vascular biology.