Evaluation of obstetric outcomes and prognostic significance of graft function in kidney transplant recipient pregnancies

Hypertens Pregnancy. 2020 May;39(2):89-94. doi: 10.1080/10641955.2020.1727498. Epub 2020 Feb 18.

Abstract

Objective: To evaluate obstetric and kidney outcomes in pregnancies with kidney transplantation.Methods: We retrospectively reviewed 32 singleton pregnancies in kidney transplant recipients. Obstetric outcomes were explored according to the estimated glomerular filtration rates (eGFR) of patients.Results: The incidences of fetal growth restriction, preeclampsia were 18.8% and 34.4%, respectively. There was a significant negative correlation between first-trimester eGFR and perinatal mortality (r = -0.546, p = .0.001) and composite adverse obstetric outcome (r = -0.415, p = .0.018).Conclusion: The degree of transplanted kidney function impairment at the beginning of pregnancy is the major determinant of pregnancy outcome.

Keywords: Kidney transplant; glomerular filtration rate; obstetric outcomes; pregnancy.

MeSH terms

  • Adult
  • Female
  • Fetal Growth Retardation / epidemiology
  • Fetal Growth Retardation / physiopathology*
  • Glomerular Filtration Rate / physiology*
  • Humans
  • Incidence
  • Kidney / physiopathology*
  • Kidney Transplantation*
  • Pre-Eclampsia / epidemiology
  • Pre-Eclampsia / physiopathology*
  • Pregnancy
  • Pregnancy Outcome
  • Prognosis
  • Retrospective Studies
  • Transplant Recipients*