Propargylamine-selective dual fluorescence turn-on method for post-synthetic labeling of DNA

Van Thang Nguyen; Anup Pandith; Young Jun Seo

doi:10.1039/d0cc00255k

Propargylamine-selective dual fluorescence turn-on method for post-synthetic labeling of DNA

Chem Commun (Camb). 2020 Mar 12;56(21):3199-3202. doi: 10.1039/d0cc00255k.

Authors

Van Thang Nguyen¹, Anup Pandith², Young Jun Seo³

Affiliations

¹ Department of Bioactive Material Sciences, Jeonbuk National University, South Korea.
² Department of Chemistry, Jeonbuk National University, South Korea. yseo@jbnu.ac.kr.
³ Department of Bioactive Material Sciences, Jeonbuk National University, South Korea and Department of Chemistry, Jeonbuk National University, South Korea. yseo@jbnu.ac.kr.

PMID: 32068200
DOI: 10.1039/d0cc00255k

Abstract

We have developed a propargylamine-selective dual fluorescence turn-on system, using ylidenemalononitrile enamines, for post-synthetic DNA labeling, allowing the direct monitoring of DNA using dual emission in living cells.

MeSH terms

Cell Line, Tumor
DNA / chemistry*
Fluorescence*
Fluorescent Dyes / chemical synthesis*
Fluorescent Dyes / chemistry
Humans
Molecular Structure
Optical Imaging
Pargyline / analogs & derivatives*
Pargyline / chemistry
Propylamines / chemistry*
Staining and Labeling

Substances

Fluorescent Dyes
Propylamines
propargylamine
DNA
Pargyline