GRASP55: A Multifunctional Protein

Hongrong Wu; Tianjiao Li; Jianfeng Zhao

doi:10.2174/1389203721666200218105302

GRASP55: A Multifunctional Protein

Curr Protein Pept Sci. 2020;21(6):544-552. doi: 10.2174/1389203721666200218105302.

Authors

Hongrong Wu¹, Tianjiao Li², Jianfeng Zhao³

Affiliations

¹ Institute of Pathogenic Biology, Hengyang Medical College, University of South China, Hengyang, China.
² Hengyang Medical College, University of South China, Hengyang, China.
³ Institute of Neuroscience, Hengyang Medical College, University of South China, Hengyang, China.

PMID: 32067616
DOI: 10.2174/1389203721666200218105302

Abstract

GRASP55 was first found as Golgi cisternae stacking protein. Due to the crucial role of Golgi in vesicular trafficking and protein modification, GRASP55 was found to function in these two aspects. Further investigation revealed that GRASP55 also participates in the unconventional secretory pathway under stress. Moreover, GRASP55 is involved in autophagy initiation and autophagosome maturation, as well as cell activity.

Keywords: Autophagy; GRASP55; Golgi; Golgin45; Unconventional secretory pathway; Vesicular trafficking.

Publication types

Review

MeSH terms

Autophagosomes / metabolism
Cell Membrane / metabolism
Endoplasmic Reticulum / metabolism*
Glycosylation
Golgi Apparatus / metabolism*
Golgi Matrix Proteins / genetics*
Golgi Matrix Proteins / metabolism
HeLa Cells
Humans
Neurons / cytology
Neurons / metabolism*
Protein Binding
Protein Interaction Mapping
Protein Processing, Post-Translational
Protein Transport
Secretory Pathway / genetics*
Signal Transduction

Substances

GORASP2 protein, human
Golgi Matrix Proteins