Red pepper seed water extract suppresses high-fat diet-induced obesity in C57BL/6 mice

Hwa-Jin Kim; Mi-Kyoung You; Ziyun Wang; Young-Hyeon Lee; Hyeon-A Kim

doi:10.1007/s10068-019-00710-9

Red pepper seed water extract suppresses high-fat diet-induced obesity in C57BL/6 mice

Food Sci Biotechnol. 2019 Dec 3;29(2):275-281. doi: 10.1007/s10068-019-00710-9. eCollection 2020 Feb.

Authors

Hwa-Jin Kim¹, Mi-Kyoung You², Ziyun Wang³, Young-Hyeon Lee³, Hyeon-A Kim³

Affiliations

¹ Hisol Inc., Namwon-si, Jeollabuk-do, Republic of Korea.
² 2Department of Nutrition and Health Sciences, University of Nebraska-Lincoln, Lincoln, NE USA.
³ 3Department of Food and Nutrition, Mokpo National University, Muan-gun, Jeollanam-do Republic of Korea.

Abstract

In this study, the protective effect of red pepper seed water extract (RPS) against the obesity in high fat diet (HFD)-fed mice was investigated (HFD control group, and HFD group treated with 100 or 200 mg/kg body weight of RPS for 13 weeks). The application of RPS partially reversed the HFD-induced increases in body weight and adipose tissue weight. The patterns of the adipose tissue weights were parallel to the patterns of fat area, as measured in DXA procedure. In the adipose tissue, RPS suppressed the expression of adipogenic transcription factors and adipose marker genes. AMP-activated protein kinase activation was observed in the adipose tissue by RPS treatment. In addition, RPS improved high homeostasis model assessment of insulin resistance and hyperlipidemia in HFD fed mice. These findings suggest that RPS can be used as a potential therapeutic substance for reducing body fat and obesity related diseases.

Keywords: Anti-obesity; HOMA-IR; High-fat diet; Lipid metabolism; Red pepper seed.