Effects of IL-22 on cardiovascular diseases

Yang Che; Zhaoliang Su; Lin Xia

doi:10.1016/j.intimp.2020.106277

Effects of IL-22 on cardiovascular diseases

Int Immunopharmacol. 2020 Apr:81:106277. doi: 10.1016/j.intimp.2020.106277. Epub 2020 Feb 14.

Authors

Yang Che¹, Zhaoliang Su², Lin Xia³

Affiliations

¹ Department of Laboratory Medicine, Affiliated Hospital of Jiangsu University, Zhenjiang 212001, China; International Genome Center, Jiangsu University, Zhenjiang 212013, China.
² International Genome Center, Jiangsu University, Zhenjiang 212013, China; Department of Immunology, Jiangsu University, Zhenjiang 212013, China.
³ Department of Laboratory Medicine, Affiliated Hospital of Jiangsu University, Zhenjiang 212001, China; International Genome Center, Jiangsu University, Zhenjiang 212013, China. Electronic address: xialinfzdx@126.com.

PMID: 32062077
DOI: 10.1016/j.intimp.2020.106277

Abstract

Interleukin-22 (IL-22), which belongs to the IL-10 family, is an alpha helix cytokine specifically produced by many lymphocytes, such as Th1, Th17, Th22, ILCs, CD4+ and CD8+ T cells. In recent years, more and more studies have demonstrated that IL-22 has an interesting relationship with various cardiovascular diseases, including myocarditis, myocardial infarction, atherosclerosis, and other cardiovascular diseases, and IL-22 signal may play a dual role in cardiovascular diseases. Here, we summarize the recent progress on the source, function, regulation of IL-22 and the effects of IL-22 signal in cardiovascular diseases. The study of IL-22 will suggest more specific strategies to maneuver these functions for the effective treatment of cardiovascular diseases and future clinical treatment.

Keywords: Cardiovascular diseases; IL-22; IL-22 receptor; Th22 cells.

Publication types

Review

MeSH terms

Animals
Cardiovascular Diseases / immunology*
Humans
Interleukin-22
Interleukins / metabolism*
Signal Transduction
T-Lymphocytes, Helper-Inducer / immunology*

Substances

Interleukins