Unraveling the role of thiosulfate sulfurtransferase in metabolic diseases

Biochim Biophys Acta Mol Basis Dis. 2020 Jun 1;1866(6):165716. doi: 10.1016/j.bbadis.2020.165716. Epub 2020 Feb 19.

Abstract

Thiosulfate sulfurtransferase (TST, EC 2.8.1.1), also known as Rhodanese, is a mitochondrial enzyme which catalyzes the transfer of sulfur in several molecular pathways. After its initial identification as a cyanide detoxification enzyme, it was found that its functions also include sulfur metabolism, modification of iron‑sulfur clusters and the reduction of antioxidants glutathione and thioredoxin. TST deficiency was shown to be strongly related to the pathophysiology of metabolic diseases including diabetes and obesity. This review summarizes research related to the enzymatic properties and functions of TST, to then explore the association between the effects of TST on mitochondria and development of diseases such as diabetes and obesity.

Keywords: Antioxidant systems; Diabetes; Obesity; Rhodanese; Sulfurtransferase; TST.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Antioxidants / metabolism*
  • Glutathione / metabolism
  • Humans
  • Iron-Sulfur Proteins / genetics
  • Metabolic Diseases / enzymology
  • Metabolic Diseases / genetics*
  • Metabolic Diseases / pathology
  • Selenium / metabolism
  • Sulfur / metabolism*
  • Thioredoxins / genetics
  • Thioredoxins / metabolism
  • Thiosulfate Sulfurtransferase / genetics*
  • Thiosulfate Sulfurtransferase / metabolism

Substances

  • Antioxidants
  • Iron-Sulfur Proteins
  • TXN protein, human
  • Thioredoxins
  • Sulfur
  • Thiosulfate Sulfurtransferase
  • Glutathione
  • Selenium