Emerging Roles for Interleukin-18 in the Gastrointestinal Tumor Microenvironment

Ka Yee Fung; Paul M Nguyen; Tracy L Putoczki

doi:10.1007/978-3-030-38315-2_5

Emerging Roles for Interleukin-18 in the Gastrointestinal Tumor Microenvironment

Adv Exp Med Biol. 2020:1240:59-72. doi: 10.1007/978-3-030-38315-2_5.

Authors

Ka Yee Fung¹, Paul M Nguyen¹, Tracy L Putoczki^{2

3}

Affiliations

¹ Personalized Oncology Division, The Walter and Eliza Hall Institute of Medical Research, Parkville, VIC, Australia.
² Personalized Oncology Division, The Walter and Eliza Hall Institute of Medical Research, Parkville, VIC, Australia. putoczki.t@wehi.edu.au.
³ Department of Medical Biology, University of Melbourne, Parkville, VIC, Australia. putoczki.t@wehi.edu.au.

PMID: 32060888
DOI: 10.1007/978-3-030-38315-2_5

Abstract

Interleukin (IL)-18, a member of the IL-1 family of cytokines, has emerged as a key regulator of mucosal homeostasis within the gastrointestinal tract. Like other members of this family, IL-18 is secreted as an inactive protein and is processed into its active form by caspase-1, although other contributors to precursor processing are emerging.Numerous studies have evaluated the role of IL-18 within the gastrointestinal tract using genetic or complementary pharmacological tools and have revealed multiple roles in tumorigenesis. Most striking among these are the divergent roles for IL-18 in colon and gastric cancers. Here, we review our current understanding of IL-18 biology and how this applies to colorectal and gastric cancers.

Keywords: Cancer; Caspase-1; Colon; Cytokines; Gastric; IFNγ, Gastrointestinal; IL-1; IL-12; IL-18; IL-18BP; Inflammation; Microenvironment; NfkB; Therapeutics.

Publication types

Review

MeSH terms

Animals
Caspase 1 / metabolism
Colorectal Neoplasms / pathology*
Humans
Interleukin-18 / metabolism*
Stomach Neoplasms / pathology*
Tumor Microenvironment*

Substances

Interleukin-18
Caspase 1