CCL21 Programs Immune Activity in Tumor Microenvironment

Sherven Sharma; Pournima Kadam; Steven Dubinett

doi:10.1007/978-3-030-36667-4_7

CCL21 Programs Immune Activity in Tumor Microenvironment

Adv Exp Med Biol. 2020:1231:67-78. doi: 10.1007/978-3-030-36667-4_7.

Authors

Sherven Sharma^{1

2

3}, Pournima Kadam⁴, Steven Dubinett^{5

4

6}

Affiliations

¹ Department of Medicine, UCLA Lung Cancer Research Program, David Geffen School of Medicine at UCLA, Los Angeles, CA, USA. SSharma@mednet.ucla.edu.
² Molecular Gene Medicine Laboratory, Veterans Affairs Greater Los Angeles Healthcare System, Los Angeles, CA, USA. SSharma@mednet.ucla.edu.
³ Jonsson Comprehensive Cancer Center, David Geffen School of Medicine at UCLA, Los Angeles, CA, USA. SSharma@mednet.ucla.edu.
⁴ Molecular Gene Medicine Laboratory, Veterans Affairs Greater Los Angeles Healthcare System, Los Angeles, CA, USA.
⁵ Department of Medicine, UCLA Lung Cancer Research Program, David Geffen School of Medicine at UCLA, Los Angeles, CA, USA.
⁶ Jonsson Comprehensive Cancer Center, David Geffen School of Medicine at UCLA, Los Angeles, CA, USA.

PMID: 32060847
DOI: 10.1007/978-3-030-36667-4_7

Abstract

CCL21 promotes immune activity in the tumor microenvironment (TME) by colocalizing dendritic cells (DC) and T cells programing ectopic lymph node architectural structures that correlate with cancer prognosis. Innovative strategies to deliver CCL21 in cancer patients will reactivate the downregulated immune activity in the TME. Immune escape mechanisms are upregulated in the TME that promote tumor immune evasion. CCL21 combined with inhibition of dominant pathways of immune evasion will aid in the development of effective immunotherapy for cancer.

Keywords: Activated T cells; Antigen-presenting cells; CCL21; Dendritic cells; Immune activity; Immune checkpoint blockade; Immune suppression; Immunotherapy; Programmed cell death protein 1 (PD-1); T cells; Tumor microenvironment.

Publication types

Review

MeSH terms

Animals
Chemokine CCL21 / immunology*
Dendritic Cells / immunology
Humans
Immunotherapy
Neoplasms / immunology*
Neoplasms / therapy*
T-Lymphocytes / immunology
Tumor Escape / immunology
Tumor Microenvironment / immunology*

Substances

CCL21 protein, human
Chemokine CCL21