The tumor microenvironment is the primary location in which tumor cells and the host immune system interact. There are many physiological, biochemical, cellular mechanisms in the neighbor of tumor which is composed of various cell types. Interactions of chemokines and chemokine receptors can recruit immune cell subsets into the tumor microenvironment. These interactions can modulate tumor progression and metastasis. In this chapter, we will focus on chemokine (C-C motif) ligand 7 (CCL7) that is highly expressed in the tumor microenvironment of various cancers, including colorectal cancer, breast cancer, oral cancer, renal cancer, and gastric cancer. We reviewed how CCL7 can affect cancer immunity and tumorigenesis by describing its regulation and roles in immune cell recruitment and stromal cell biology.
Keywords: Antitumor effect; CCL7; CCRs; Cancer-associated adipocytes; Cancer-associated fibroblast; Clinical trials; Combination treatment; Immune cell infiltration; Immunotherapy; Metastasis; Pro-tumor effect; Prognosis; Proliferation; Tumor microenvironment; Tumor-associated macrophage.