Association between dyslipidemia and serum uric acid levels in Korean adults: Korea National Health and Nutrition Examination Survey 2016-2017

PLoS One. 2020 Feb 14;15(2):e0228684. doi: 10.1371/journal.pone.0228684. eCollection 2020.

Abstract

Objectives: Despite the growing pieces of evidence linking hyperuricemia with metabolic syndrome and cardiovascular disease, the relationship between dyslipidemia and serum uric acid has not yet been established. This study aimed to investigate the association between individual components of dyslipidemia and serum uric acid by using the nationally representative Korea National Health and Nutrition Examination Survey 2016-2017.

Methods: A total of 8,722 participants (age ≥ 19 years) without missing values were analyzed for this study. Serum uric acid levels according to the presence of individual dyslipidemia components were calculated using multivariable-adjusted general linear models (GLM). Odds ratios of individual dyslipidemia components to hyperuricemia were calculated using unadjusted and multivariable-adjusted logistic regression analysis.

Results: A total of 1,061 participants were identified as having hyperuricemia, with a prevalence of 12.2%. Multivariable-adjusted GLM demonstrated a significant trend between individual dyslipidemia components and serum uric acid levels (P < 0.05). A positive association between the numbers of dyslipidemia components and the increments of serum uric acid levels was also observed (P < 0.001). In multivariable-adjusted logistic regression analysis, odds ratios (OR) and 95% confidence interval (CI) of all dyslipidemia components to hyperuricemia were shown to be statistically significant (P < 0.05). When further adjusted for the combined components themselves, each 10 mg/dL increments of total cholesterol (OR 1.053; 95% CI 1.028-1.079), triglycerides (OR 1.017; 95% CI 1.009-1.026) and HDL-C (OR 0.804; 95% CI 0.729-0.887), retained significant correlation with hyperuricemia.

Conclusion: Our study demonstrated that the dyslipidemia components of serum total cholesterol, triglycerides and LDL-C levels are positively associated with serum uric acid levels, whereas serum HDL-C levels are inversely related. Further complementary studies regarding other lipid parameters are needed to confirm the accurate association between dyslipidemia and serum uric acid levels.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Dyslipidemias / blood
  • Dyslipidemias / epidemiology*
  • Female
  • Health Surveys
  • Humans
  • Hyperuricemia / blood
  • Hyperuricemia / epidemiology*
  • Male
  • Middle Aged
  • Republic of Korea
  • Uric Acid / blood*

Substances

  • Uric Acid

Grants and funding

This work was supported by the Radianqbio Inc. (2018, GI06530). The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. The funders have not served or currently serve on the editorial board. The funders have not acted as an expert witness in relevant legal proceedings. The funders have not sat or currently sit on a committee for an organization that may benefit form publication of the paper.