Correlation between higher-order aberrations and visual acuity recovery (CoHORT) after spectacles treatment for pediatric refractive amblyopia: A pilot study using iDesign measurement

PLoS One. 2020 Feb 14;15(2):e0228922. doi: 10.1371/journal.pone.0228922. eCollection 2020.

Abstract

Purpose: To determine the correlation between higher-order aberrations (HOAs) and best-corrected visual acuity (BCVA) recovery speed after spectacles treatment using iDesign measurements in refractive amblyopic children.

Methods: This is a prospective case series. Children aged from 3 to 7 years with refractive amblyopia (Landolt C equivalent < 0.8) were recruited. All participants were followed for at least 6 months after full correction of the refraction error by spectacles. The HOAs were measured using iDesign before and after cycloplegia at first visit and at 3-month intervals. Then correlation between BCVA recovery after treatment for 6 months and HOAs was determined.

Results: We analyzed 24 eyes of 12 children (mean age, 4.5 years). Baseline mean BCVA was logarithm of minimal angle of resolution (logMAR) 0.335 (Landolt C equivalent 0.46), which improved to logMAR 0.193 (Landolt C equivalent 0.64) after treatment with full-correction spectacles for 6 months. The amblyopic eye BCVA recovery was negatively correlated with tetrafoil with/without cycloplegia (P = 0.006 and 0.022, respectively) and trefoil with cycloplegia (P = 0.049).

Conclusions: trefoil and tetrafoil measured with iDesign negatively correlates with the BCVA recovery speed of refractive amblyopic eyes after spectacles treatment in this pilot study. The current study results may aid in further investigation for diagnosis and treatment of refractory refractive and idiopathic amblyopia.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Amblyopia / diagnosis
  • Amblyopia / therapy*
  • Child
  • Child, Preschool
  • Cohort Studies
  • Eyeglasses
  • Female
  • Follow-Up Studies
  • Humans
  • Male
  • Pilot Projects
  • Prospective Studies
  • Refraction, Ocular
  • Refractive Errors / therapy
  • Treatment Outcome
  • Visual Acuity / physiology*

Grants and funding

Publication of this article is supported by the research grant CMRPG 2E0201-2E0202 from Chang Gung Memorial Hospital, Keelung, Taiwan. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.