A solid support generator of the Auger electron emitter rhodium-103m from [103Pd]palladium

Andreas I Jensen; Fedor Zhuravlev; Gregory Severin; Charlotte Busk Magnus; Jesper Fonslet; Ulli Köster; Mikael Jensen

doi:10.1016/j.apradiso.2019.108985

A solid support generator of the Auger electron emitter rhodium-103m from [¹⁰³Pd]palladium

Appl Radiat Isot. 2020 Feb:156:108985. doi: 10.1016/j.apradiso.2019.108985. Epub 2019 Nov 14.

Authors

Andreas I Jensen¹, Fedor Zhuravlev², Gregory Severin³, Charlotte Busk Magnus², Jesper Fonslet², Ulli Köster⁴, Mikael Jensen²

Affiliations

¹ Center for Nuclear Technologies (DTU Nutech), Technical University of Denmark (DTU), Frederiksborgvej 399, 4000, Roskilde, Denmark. Electronic address: atije@dtu.dk.
² Center for Nuclear Technologies (DTU Nutech), Technical University of Denmark (DTU), Frederiksborgvej 399, 4000, Roskilde, Denmark.
³ Center for Nuclear Technologies (DTU Nutech), Technical University of Denmark (DTU), Frederiksborgvej 399, 4000, Roskilde, Denmark; Department of Chemistry and Facility for Rare Isotope Beams, Michigan State University, 578 S. Shaw Ln., East Lansing, MI, 48824, USA. Electronic address: gwseverin@chemistry.msu.edu.
⁴ Institut Laue-Langevin, 71 Avenue des Martyrs, 38042, Grenoble, France. Electronic address: koester@ill.fr.

PMID: 32056685
DOI: 10.1016/j.apradiso.2019.108985

Abstract

Auger electron therapy is an attractive modality for targeting microscopic tumors. Rhodium-103 m (^103mRh, T_½ = 56.1 min) is a promising Auger electron emitter that can be obtained as the decay product of palladium-103 (¹⁰³Pd, T_½ = 16.99 days). ¹⁰³Pd was chelated in a lipophilic derivative of the 16aneS4 macrocycle and the complex was trapped on a C18 cartridge. Elution with dilute hydrochloric acid gave radiochemically pure ^103mRh. We hypothesize this to be through a combination of the Szilard-Chalmers effect and transient ionization.

Keywords: 16aneS4; Auger radiotherapy; Palladium-103; Radionuclide generator; Rhodium-103m.