Long non-coding RNAs as novel diagnostic and therapeutic targets in kidney disease

Qin Zhou; Wei Chen; Xue-Qing Yu

doi:10.1016/j.cdtm.2019.12.004

Long non-coding RNAs as novel diagnostic and therapeutic targets in kidney disease

Chronic Dis Transl Med. 2020 Jan 8;5(4):252-257. doi: 10.1016/j.cdtm.2019.12.004. eCollection 2019 Dec.

Authors

Qin Zhou^{1

2

3}, Wei Chen^{1

2

3}, Xue-Qing Yu^{1

2

3

4}

Affiliations

¹ Department of Nephrology, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, Guangdong 510080, China.
² National Health Commission Key Laboratory of Nephrology, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, Guangdong 510080, China.
³ Guangdong Provincial Key Laboratory of Nephrology, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, Guangdong 510080, China.
⁴ Guangdong General Hospital, Guangzhou, Guangdong, 510080, China.

Abstract

Long non-coding RNAs (lncRNAs) have critical roles in the development of many diseases including kidney disease. An increasing number of studies have shown that lncRNAs are involved in kidney development and that their dysregulation can result in distinct disease processes, including acute kidney injury (AKI), chronic kidney disease (CKD), and renal cell carcinoma (RCC). Understanding the roles of lncRNAs in kidney disease may provide new diagnostic and therapeutic opportunities in the clinic. This review provides an overview of lncRNA characteristics, biological function and discusses specific studies that provide insight into the function and potential application of lncRNAs in kidney disease treatment.

Keywords: Diabetic nephritis; Kidney disease; Long non-coding RNAs; Renal cell carcinoma; Renal fibrosis; Renal inflammation.

Publication types

Review