Effect of Stellaria media Tea on Lipid Profile in Rats

Virág Demján; Tivadar Kiss; Andrea Siska; Márton Richárd Szabó; Márta Sárközy; Imre Földesi; Dezső Csupor; Tamás Csont

doi:10.1155/2020/5109328

Effect of Stellaria media Tea on Lipid Profile in Rats

Evid Based Complement Alternat Med. 2020 Jan 24:2020:5109328. doi: 10.1155/2020/5109328. eCollection 2020.

Authors

Virág Demján^{1

2

3}, Tivadar Kiss^{2

4}, Andrea Siska⁵, Márton Richárd Szabó^{1

2

3}, Márta Sárközy^{1

2

3}, Imre Földesi⁵, Dezső Csupor^{2

4}, Tamás Csont^{1

2

3}

Affiliations

¹ University of Szeged, Faculty of Medicine, Department of Biochemistry, Metabolic Diseases and Cell Signaling Group (MEDICS), 6720 Szeged, Dóm tér 9, Hungary.
² University of Szeged, Interdisciplinary Centre for Natural Products, 6720 Szeged, Eötvös utca 6, Hungary.
³ University of Szeged, Interdisciplinary Centre of Excellence, 6720 Szeged, Dugonics tér 13, Hungary.
⁴ University of Szeged, Faculty of Pharmacy, Department of Pharmacognosy, 6720 Szeged, Eötvös utca 6, Hungary.
⁵ University of Szeged, Faculty of Medicine, Department of Laboratory Medicine, 6725 Szeged, Semmelweis utca 6, Hungary.

Abstract

Background: In folk medicine, common chickweed (Stellaria media) has traditionally been applied for the treatment of hypercholesterolemia; however, there is no firm experimental proof to support the rationale of this practice. Therefore, we aimed to assess the efficacy and safety of Stellaria media) has traditionally been applied for the treatment of hypercholesterolemia; however, there is no firm experimental proof to support the rationale of this practice. Therefore, we aimed to assess the efficacy and safety of Materials and Methods. Adult male Wistar rats were divided into 3 groups. The (i) control group received standard laboratory chow, the (ii) hypercholesterolemic group received cholesterol-enriched diet, and the (iii) chickweed-treated hypercholesterolemic group received cholesterol-enriched diet and 100 mg/kg body weight Stellaria media) has traditionally been applied for the treatment of hypercholesterolemia; however, there is no firm experimental proof to support the rationale of this practice. Therefore, we aimed to assess the efficacy and safety of.

Results: Cholesterol-enriched diet significantly increased serum total cholesterol, LDL- and HDL-cholesterol levels, but did not affect triacylglycerol concentrations. The addition of chickweed to the diet did not cause any significant change in serum lipid profile or body weight increase. Liver and kidney functions were unaltered and cardiac morphology and function were not changed due to Stellaria media) has traditionally been applied for the treatment of hypercholesterolemia; however, there is no firm experimental proof to support the rationale of this practice. Therefore, we aimed to assess the efficacy and safety of.

Conclusion: Although chickweed does not seem to be toxic, our results do not support the rationale of its use in the treatment of hypercholesterolemia.