Rapid phenotyping towards personalized malaria medicine

Malar J. 2020 Feb 11;19(1):68. doi: 10.1186/s12936-020-3149-4.

Abstract

Malaria is major public health concerns which continues to claim the lives of more than 435,000 people each year. The challenges with anti-malarial drug resistance and detection of low parasitaemia forms an immediate barrier to achieve the fast-approaching United Nations Sustainable Development Goals of ending malaria epidemics by 2030. In this Opinion article, focusing on the recent published technologies, in particularly the nuclear magnetic resonance (NMR)-based diagnostic technologies, the authors offer their perspectives and highlight ways to bring these point-of-care technologies towards personalized medicine. To this end, they advocate an open sourcing initiative to rapidly close the gap between technological innovations and field implementation.

Keywords: Malaria control and elimination; Personalized medicine; Technological innovations.

MeSH terms

  • Animals
  • Drug Resistance
  • Hemeproteins / analysis*
  • Hemeproteins / chemistry
  • Hemeproteins / metabolism
  • Humans
  • Magnetic Resonance Spectroscopy / methods*
  • Malaria / diagnosis*
  • Malaria / epidemiology
  • Malaria / parasitology
  • Phenotype
  • Plasmodium / classification
  • Plasmodium / drug effects
  • Plasmodium / genetics
  • Point-of-Care Testing*
  • Precision Medicine / methods*
  • Sensitivity and Specificity

Substances

  • Hemeproteins
  • hemozoin