Tumor-targeting and redox-sensitive micelles based on hyaluronic acid conjugate for delivery of paclitaxel

J Biomater Appl. 2020 May;34(10):1458-1469. doi: 10.1177/0885328220905256. Epub 2020 Feb 11.

Authors

Jiyang Liu¹, Na Liang², Shupeng Li¹, Yang Han¹, Pengfei Yan¹, Yoshiaki Kawashima³, Fude Cui⁴, Shaoping Sun¹

Affiliations

¹ Department of Pharmaceutical Engineering, School of Chemistry and Material Science, Heilongjiang University, Harbin, China.
² Department of Pharmaceutical Engineering, College of Chemistry & Chemical Engineering, Harbin Normal University, Harbin, China.
³ Department of Pharmaceutical Engineering, School of Pharmacy, Aichi Gakuin University, Nagoya, Japan.
⁴ School of Pharmacy, Shenyang Pharmaceutical University, Shenyang, China.

PMID: 32046573
DOI: 10.1177/0885328220905256

No abstract available

Keywords: Hyaluronic acid; disulfide bridges; hexadecanol; mPEG; micelles.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Animals
Antineoplastic Agents / administration & dosage*
Antineoplastic Agents / chemistry
Antineoplastic Agents / pharmacology
Cell Line, Tumor
Disulfides / chemistry
Drug Delivery Systems*
Hemolysis
Humans
Hyaluronic Acid / chemistry*
In Vitro Techniques
MCF-7 Cells
Mice
Micelles*
Microscopy, Electron, Transmission
Neoplasms / drug therapy*
Neoplasms / metabolism*
Oxidation-Reduction*
Paclitaxel / administration & dosage*
Polyethylene Glycols / chemistry
Polymers / chemistry
Rabbits
Tetrazolium Salts / chemistry
Thiazoles / chemistry
X-Ray Diffraction

Substances

Antineoplastic Agents
Disulfides
Micelles
Polymers
Tetrazolium Salts
Thiazoles
Polyethylene Glycols
Hyaluronic Acid
thiazolyl blue
Paclitaxel