Centromere chromatin structure - Lessons from neocentromeres

Catherine Naughton; Nick Gilbert

doi:10.1016/j.yexcr.2020.111899

Centromere chromatin structure - Lessons from neocentromeres

Exp Cell Res. 2020 Apr 15;389(2):111899. doi: 10.1016/j.yexcr.2020.111899. Epub 2020 Feb 8.

Authors

Catherine Naughton¹, Nick Gilbert²

Affiliations

¹ Medical Research Council Human Genetics Unit, Institute of Genetics and Molecular Medicine, The University of Edinburgh, Edinburgh, UK. Electronic address: catherine.naughton@ed.ac.uk.
² Medical Research Council Human Genetics Unit, Institute of Genetics and Molecular Medicine, The University of Edinburgh, Edinburgh, UK.

PMID: 32044308
DOI: 10.1016/j.yexcr.2020.111899

Abstract

Centromeres are highly specialized genomic loci that function during mitosis to maintain genome stability. Formed primarily on repetitive α-satellite DNA sequence characterisation of native centromeric chromatin structure has remained challenging. Fortuitously, neocentromeres are formed on a unique DNA sequence and represent an excellent model to interrogate centromeric chromatin structure. This review uncovers the specific findings from independent neocentromere studies that have advanced our understanding of canonical centromere chromatin structure.

Keywords: Centromere; Chromatin; Neocentromere; α-satellite.

Publication types

Research Support, Non-U.S. Gov't
Review

MeSH terms

Animals
Autoantigens*
Centromere / genetics*
Chromatin / chemistry*
Chromatin / genetics*
Chromosome Segregation*
Epigenesis, Genetic*
Humans
Meiosis*

Substances

Autoantigens
Chromatin

Abstract

Publication types

MeSH terms

Substances

Grants and funding