Stabilizing Peri-Stent Restenosis Using a Novel Therapeutic Carrier

Patrick H Kee; Melanie R Moody; Shao-Ling Huang; Hyunggun Kim; Xing Yin; Tao Peng; Susan T Laing; Melvin E Klegerman; Mohammad H Rahbar; Deborah Vela; Curtis Genstler; Kevin J Haworth; Christy K Holland; David D McPherson

doi:10.1016/j.jacbts.2019.09.005

Stabilizing Peri-Stent Restenosis Using a Novel Therapeutic Carrier

JACC Basic Transl Sci. 2019 Nov 28;5(1):1-11. doi: 10.1016/j.jacbts.2019.09.005. eCollection 2020 Jan.

Authors

Affiliations

¹ Department of Internal Medicine, The University of Texas Health Science Center at Houston, Houston, Texas.
² Department of Bio-Mechatronic Engineering, Sungkyunkwan University, Suwon, Republic of Korea.
³ Center for Clinical and Translational Sciences, The University of Texas Health Science Center at Houston, Houston, Texas.
⁴ Department of Pathology, Texas Heart Institute, Houston, Texas.
⁵ EKOS Corporation, Bothell, Washington.
⁶ Department of Biomedical Engineering, University of Cincinnati, Cincinnati, Ohio.

Abstract

Late in-stent restenosis remains a significant problem. Bare-metal stents were implanted into peripheral arteries in miniature swine, followed by direct intra-arterial infusion of nitric oxide-loaded echogenic liposomes (ELIPs) and anti-intercellular adhesion molecule-1 conjugated ELIPs loaded with pioglitazone exposed to an endovascular catheter with an ultrasonic core. Ultrasound-facilitated delivery of ELIP formulations into stented peripheral arteries attenuated neointimal growth. Local atheroma-targeted, ultrasound-triggered delivery of nitric oxide and pioglitazone, an anti-inflammatory peroxisome proliferator-activated receptor-γ agonist, into stented arteries has the potential to stabilize stent-induced neointimal growth and obviate the need for long-term antiplatelet therapy.

Keywords: ELIP, echogenic liposome; ICAM, intercellular adhesion molecule; IVUS, intravascular ultrasound; NO, nitric oxide; PGN, pioglitazone; SPDP, 3-(2-pyridyldithio propionic acid)-N-hydroxysuccinimide ester; atherosclerosis; in-stent restenosis; nitric oxide; pioglitazone; ultrasound contrast agent.

Abstract

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