This study examined the relationship between religious orientation and death attitudes in Christian U.S. students and Muslim Turkish students. It also assessed whether meaning in life mediated these relationships. Multivariate statistics and path analyses were conducted to identify significant predictors of death attitudes in these groups. Intrinsic religiosity was more consistently associated with positive attitudes toward death than extrinsic religiosity, and these patterns remained consistent across groups. Meaning in life mediated some of these relationships, although not consistently. Evidence suggesting differential relationships between religiosity and death attitudes across groups was found, although the overall results suggest more similarities than differences.