The relationship between areca nut as a primary carcinogen and oral cancer has been widely concerned. Areca can change the levels of reactive oxygen species (ROS) and autophagy in cells, and the levels of ROS and autophagy are closely related to the occurrence and development of tumors. This paper reviewed the relationships among areca nut, intracellular ROS, and autophagy.
槟榔作为一级致癌物，其与口腔癌的关系受到广泛关注。活性氧（ROS）及自噬水平与肿瘤的发生发展密切相关，研究发现槟榔可诱发细胞内ROS及自噬水平变化。本文结合相关研究进展，对槟榔、细胞内ROS以及自噬之间的关系进行综述。.
Keywords: areca nut; autophagy; oral cavity cancer; oral submucous fibrosis; reactive oxygen species.