Subtelomeric Transcription and its Regulation

Marta Kwapisz; Antonin Morillon

doi:10.1016/j.jmb.2020.01.026

Subtelomeric Transcription and its Regulation

J Mol Biol. 2020 Jul 10;432(15):4199-4219. doi: 10.1016/j.jmb.2020.01.026. Epub 2020 Feb 6.

Authors

Marta Kwapisz¹, Antonin Morillon²

Affiliations

¹ Laboratoire de Biologie Moléculaire Eucaryote, Centre de Biologie Intégrative (CBI), Université de Toulouse, CNRS, UPS, France.
² ncRNA, Epigenetic and Genome Fluidity, CNRS UMR 3244, Sorbonne Université, PSL University, Institut Curie, Centre de Recherche, 26 rue d'Ulm, 75248, Paris, France. Electronic address: antonin.morillon@curie.fr.

Abstract

The subtelomeres, highly heterogeneous repeated sequences neighboring telomeres, are transcribed into coding and noncoding RNAs in a variety of organisms. Telomereproximal subtelomeric regions produce non-coding transcripts i.e., ARRET, αARRET, subTERRA, and TERRA, which function in telomere maintenance. The role and molecular mechanisms of the majority of subtelomeric transcripts remain unknown. This review depicts the current knowledge and puts into perspective the results obtained in different models from yeasts to humans.

Keywords: noncoding RNA; repeated sequences; subtelomeres; transcription.

Publication types

Research Support, Non-U.S. Gov't
Review

MeSH terms

Animals
Gene Expression Regulation
Humans
RNA, Untranslated / genetics*
Telomere / genetics*
Telomere Homeostasis
Transcription, Genetic
Yeasts / genetics

Substances

RNA, Untranslated