Rod-based urchin-like hollow microspheres of Bi2S3: Facile synthesis, photo-controlled drug release for photoacoustic imaging and chemo-photothermal therapy of tumor ablation

Chenyang Zhang; Dongdong Li; Pei Pei; Wanni Wang; Benjin Chen; Zhaoyou Chu; Zhengbao Zha; Xianzhu Yang; Jinbing Wang; Haisheng Qian

doi:10.1016/j.biomaterials.2020.119835

Rod-based urchin-like hollow microspheres of Bi₂S₃: Facile synthesis, photo-controlled drug release for photoacoustic imaging and chemo-photothermal therapy of tumor ablation

Biomaterials. 2020 Apr:237:119835. doi: 10.1016/j.biomaterials.2020.119835. Epub 2020 Feb 1.

Authors

Chenyang Zhang¹, Dongdong Li², Pei Pei³, Wanni Wang³, Benjin Chen³, Zhaoyou Chu³, Zhengbao Zha³, Xianzhu Yang⁴, Jinbing Wang⁵, Haisheng Qian⁶

Affiliations

¹ School of Biomedical Engineering, Research and Engineering Center of Biomedical Materials, Anhui Medical University, Hefei, 230032, PR China; School of Food and Biological Engineering, Hefei University of Technology, Hefei, 230009, PR China.
² Guangzhou First People's Hospital, School of Medicine, South China University of Technology, Guangzhou, Guangdong, 510006, China.
³ School of Food and Biological Engineering, Hefei University of Technology, Hefei, 230009, PR China.
⁴ Guangzhou First People's Hospital, School of Medicine, South China University of Technology, Guangzhou, Guangdong, 510006, China; Guangzhou Regenerative Medicine and Health Guangdong Laboratory, 510005, Guangzhou, China. Electronic address: yangxz@scut.edu.cn.
⁵ Department of Oral and Maxillofacial-Head and Neck Oncology, Shanghai Ninth People's Hospital, College of Stomatology, Shanghai Jiao Tong University School of Medicine, Shanghai Key Laboratory of Stomatology & Shanghai Research Institute of Stomatology, National Clinical Center for Oral Disease, 639 Zhizaoju Road, Shanghai, 200011, PR China. Electronic address: wangjinbing@aliyun.com.
⁶ School of Biomedical Engineering, Research and Engineering Center of Biomedical Materials, Anhui Medical University, Hefei, 230032, PR China. Electronic address: shqian@mail.ustc.edu.cn.

PMID: 32035321
DOI: 10.1016/j.biomaterials.2020.119835

Abstract

Hollow nanostructures have been evoked considerable attention owing to their intriguing hollow interior for important and potential applications in drug delivery, lithium battery, catalysis and etc. Herein, Bi₂S₃ hollow microspheres with rod-based urchin-like nanostructures (denoted as U-BSHM) were synthesized through a facile and rapid ion exchanging method using a particular hard template. The growth mechanism of the U-BSHM has been investigated and illustrated by the morphological evolution of the different samples at early stages. The obtained U-BSHM exhibited strong and wide UV-vis-NIR absorption ability and outstanding photothermal conversion efficiency. Thus, the U-BSHM can be used as spatio-temporal precisely controlled carrier by loading the mixture of 1-tetradecanol (phase change material, PCM) with melting point around 38 °C and hydrophilic chemotherapeutic doxorubicin hydrochloride (denoted as DOX) into the hollow interior to form (PCM + DOX)@Bi₂S₃ nanocomposites (denoted as PD@BS) for photoacoustic (PA) imaging and chemo-photothermal therapy of the tumors. When exposed to 808 nm near infrared light (NIR) laser irradiation, this nanocomposites could elevate the temperature of the surroundings by absorption and conversion of the NIR photons into heat energy, which inducing the triggered release of DOX from the hollow interior once the temperature reach up to the melting point of PCM. The killing efficiency of the chemo-photothermal therapy was systematically validated both in vitro and in vivo. In the meanwhile, the implanted tumor was completely restrained through PA imaging and combined therapies. Therefore, this kind of urchin-like hollow nanostructures would be used as important candidates for the multimodal bioimaging and therapy of tumors.

Keywords: Bi(2)S(3); Chemo-photothermal therapy; Photo-controlled drug release; Photoacoustic imaging; Sacrificed template method.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Cell Line, Tumor
Doxorubicin
Drug Liberation
Humans
Hyperthermia, Induced*
Microspheres
Nanoparticles*
Neoplasms*
Pharmaceutical Preparations*
Photoacoustic Techniques*
Phototherapy
Photothermal Therapy

Substances

Pharmaceutical Preparations
Doxorubicin