Effect of ion doping in silica-based nanoparticles on the hemolytic and oxidative activity in contact with human erythrocytes

Abstract

Aim: The aim of this study was the synthesis of ion doped silica-based nanoparticles and the evaluation of their toxic effect on erythrocytes.

Materials & methods: Their synthesis was performed using the sol-gel method, by the progressive addition of calcium, magnesium and copper ions on pure silica nanoparticles. The toxicity evaluation was based on hemolysis, lipid peroxidation, ROS, H₂O₂ species and antioxidant enzyme production.

Results: The addition of Mg and Cu in the SNs presented better hemocompatibility by protecting erythrocytes from oxidative stress.

Conclusion: Ion doping with magnesium in the investigated calcium silicate system induces a protective effect in erythrocyte membrane in compare with pure silica nanoparticles.

Keywords: Erythrocytes; Ion doping; Oxidative stress; Silica-based nanoparticles.