Organoids Develop Motor Skills: 3D Human Neuromuscular Junctions

Justin K Ichida; Chien-Ping Ko

doi:10.1016/j.stem.2020.01.003

Organoids Develop Motor Skills: 3D Human Neuromuscular Junctions

Cell Stem Cell. 2020 Feb 6;26(2):131-133. doi: 10.1016/j.stem.2020.01.003.

Authors

Justin K Ichida¹, Chien-Ping Ko²

Affiliations

¹ Department of Stem Cell Biology and Regenerative Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA 90033, USA; Eli and Edythe Broad CIRM Center for Regenerative Medicine and Stem Cell Research at USC, Los Angeles, CA 90033, USA; Zilkha Neurogenetic Institute, Keck School of Medicine, University of Southern California, Los Angeles, CA 90033, USA. Electronic address: ichida@usc.edu.
² Section of Neurobiology, Department of Biological Sciences, University of Southern California, Los Angeles, CA 90089, USA.

PMID: 32032521
DOI: 10.1016/j.stem.2020.01.003

Abstract

Stem cell technology enables the production of three-dimensional organ-like structures, but engineering multi-tissue anatomy has proven difficult. In this issue of Cell Stem Cell, Martins et al. (2020) show that generating a common progenitor cell for posterior spinal cord and muscle enables the formation of functional neuromuscular junctions in single organoids.

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MeSH terms

Humans
Motor Skills*
Neuromuscular Junction
Organoids*
Stem Cells
Tissue Engineering