Keeping Fibrotic Responses in Contractile Tissues at Bay: The Plot t(Hic1)ens

Johnny Kim; Thomas Braun

doi:10.1016/j.stem.2019.12.010

Keeping Fibrotic Responses in Contractile Tissues at Bay: The Plot t(Hic1)ens

Cell Stem Cell. 2020 Feb 6;26(2):129-130. doi: 10.1016/j.stem.2019.12.010.

Authors

Johnny Kim¹, Thomas Braun²

Affiliations

¹ Department of Cardiac Development and Remodeling, Max Planck Institute for Heart and Lung Research, 61231 Bad Nauheim, Germany, The German Center for Cardiovascular Research (DZHK), Partner Site Rhine-Main.
² Department of Cardiac Development and Remodeling, Max Planck Institute for Heart and Lung Research, 61231 Bad Nauheim, Germany, The German Center for Cardiovascular Research (DZHK), Partner Site Rhine-Main. Electronic address: thomas.braun@mpi-bn.mpg.de.

PMID: 32032520
DOI: 10.1016/j.stem.2019.12.010

Abstract

Two recent papers in Cell Stem Cell by Soliman et al. (2020) and Scott et al. (2019) explore the contributions of mesenchymal progenitor cells to fibrosis in heart and skeletal muscle. They find tissue-dependent roles for a subpopulation of mesenchymal progenitors expressing Hic1 with varied differentiation capacities and pathophysiologic contributions.

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MeSH terms

Cell Differentiation
Cell Division
Fibrosis
Humans
Kruppel-Like Transcription Factors
Mesenchymal Stem Cells*
Muscle, Skeletal

Substances

HIC1 protein, human
Kruppel-Like Transcription Factors