Clinical study of octacalcium phosphate and collagen composite in oral and maxillofacial surgery

Tadashi Kawai; Shinji Kamakura; Keiko Matsui; Masayuki Fukuda; Hiroshi Takano; Mitsuyoshi Iino; Shigeo Ishikawa; Hiromasa Kawana; Tomoya Soma; Eisaku Imamura; Hideki Kizu; Aya Michibata; Izumi Asahina; Keiichiro Miura; Norifumi Nakamura; Toshiro Kibe; Osamu Suzuki; Tetsu Takahashi

doi:10.1177/2041731419896449

Clinical study of octacalcium phosphate and collagen composite in oral and maxillofacial surgery

J Tissue Eng. 2020 Jan 23:11:2041731419896449. doi: 10.1177/2041731419896449. eCollection 2020 Jan-Dec.

Authors

Tadashi Kawai¹, Shinji Kamakura², Keiko Matsui¹, Masayuki Fukuda³, Hiroshi Takano³, Mitsuyoshi Iino⁴, Shigeo Ishikawa⁴, Hiromasa Kawana^{5

6}, Tomoya Soma⁵, Eisaku Imamura⁷, Hideki Kizu⁸, Aya Michibata⁹, Izumi Asahina¹⁰, Keiichiro Miura¹⁰, Norifumi Nakamura¹¹, Toshiro Kibe¹¹, Osamu Suzuki¹², Tetsu Takahashi¹

Affiliations

¹ Department of Oral Medicine and Surgery, Division of Oral and Maxillofacial Surgery, Tohoku University Graduate School of Dentistry, Sendai, Japan.
² Department of Bone Regenerative Engineering, Division of Regenerative and Biomedical Engineering, Tohoku University Graduate School of Biomedical Engineering, Sendai, Japan.
³ Department of Dentistry and Oral Surgery, Akita University Graduate School of Medicine, Akita, Japan.
⁴ Department of Dentistry, Oral and Maxillofacial-Plastic and Reconstructive Surgery, School of Medicine, Yamagata University, Yamagata, Japan.
⁵ Department of Dentistry and Oral Surgery, Division of Oral and Maxillofacial Surgery, School of Medicine, Keio University, Tokyo, Japan.
⁶ Department of Oral and Maxillofacial Implantology, Kanagawa Dental University, Kanagawa, Japan.
⁷ Department of Oral and Maxillofacial Surgery, Yokohama General Hospital, Kanagawa, Japan.
⁸ Department of Dentistry and Oral Surgery, Tachikawa Hospital, Tachikawa, Japan.
⁹ Department of Oral Surgery, Shizuoka City Shimizu Hospital, Shizuoka, Japan.
¹⁰ Department of Regenerative Oral Surgery, Medical and Dental Sciences, Graduate School of Biomedical Sciences, Nagasaki University, Nagasaki, Japan.
¹¹ Department of Oral and Maxillofacial Surgery, Field of Oral and Maxillofacial Rehabilitation, Graduate School of Medical and Dental Sciences, Kagoshima University, Kagoshima, Japan.
¹² Department of Craniofacial Engineering and Regeneration, Division of Craniofacial Function Engineering, Tohoku University Graduate School of Dentistry, Sendai, Japan.

Abstract

Octacalcium phosphate and its collagen composite have been recognized as bone substitute materials possessing osteoconductivity and biodegradation properties. We evaluated the effectiveness of octacalcium phosphate and its collagen composite used for bone augmentation in major oral and maxillofacial surgeries in a clinical trial. Octacalcium phosphate and its collagen composite were used in cases of sinus floor elevation in 1- and 2-stage, socket preservation, cyst, and alveolar cleft procedures. A total of 60 patients were evaluated for effectiveness after the implantation of octacalcium phosphate and its collagen composite. Although sinus floor elevation in 1-stage, cyst, and alveolar cleft cases met the criteria for the judgment of success, sinus floor elevation in 2-stage and socket preservation groups did not meet the criteria in the initial evaluation. However, an additional evaluation for reconfirmation revealed the effectiveness of octacalcium phosphate and its collagen composite in those groups, and all evaluation results ultimately indicated the success of this clinical trial. Therefore, this clinical trial suggested that application of octacalcium phosphate and its collagen composite for oral and maxillofacial surgery was safe and effective and that octacalcium phosphate and its collagen composite could be a bone substitute candidate instead of autologous bone.

Keywords: Octacalcium phosphate; bone augmentation; bone substitute material; clinical trial; collagen composite.