Photons as a 21st century reagent

Holly E Bonfield; Thomas Knauber; François Lévesque; Eric G Moschetta; Flavien Susanne; Lee J Edwards

doi:10.1038/s41467-019-13988-4

Photons as a 21st century reagent

Nat Commun. 2020 Feb 6;11(1):804. doi: 10.1038/s41467-019-13988-4.

Authors

Holly E Bonfield^{1

2}, Thomas Knauber³, François Lévesque⁴, Eric G Moschetta⁵, Flavien Susanne¹, Lee J Edwards⁶

Affiliations

¹ Chemical Development, GSK, Gunnels Wood Road, Stevenage, Hertfordshire, SG1 2NY, UK.
² Department of Pure and Applied Chemistry WestCHEM, University of Strathclyde 295 Cathedral Street, Glasgow, Scotland, G1 1XL, UK.
³ Medicinal Sciences, Worldwide Research and Development, Pfizer, Inc., Eastern Point Road, Groton, Connecticut, 06340, USA.
⁴ Process Research & Development, Merck & Co., Inc., Rahway, New Jersey, 07065, USA.
⁵ Process Research & Development, AbbVie, Inc., 1401 Sheridan Road, North Chicago, Illinois, 60064, USA.
⁶ Chemical Development, GSK, Gunnels Wood Road, Stevenage, Hertfordshire, SG1 2NY, UK. Lee.J.Edwards@gsk.com.

Abstract

A pharmaceutical industry viewpoint on how the fundamental laws of photochemistry are used to identify the parameters required to implement photochemistry from lab to scale. Parameters such as photon stoichiometry and light intensity are highlighted within to inform future publications.