FVC variability in patients with idiopathic pulmonary fibrosis and role of 6-min walk test to predict further change

Steven D Nathan; Ming Yang; Elizabeth A Morgenthien; John L Stauffer

doi:10.1183/13993003.02151-2019

FVC variability in patients with idiopathic pulmonary fibrosis and role of 6-min walk test to predict further change

Eur Respir J. 2020 May 14;55(5):1902151. doi: 10.1183/13993003.02151-2019. Print 2020 May.

Authors

Steven D Nathan¹, Ming Yang², Elizabeth A Morgenthien², John L Stauffer²

Affiliations

¹ Inova Fairfax Hospital, Falls Church, VA, USA Steven.Nathan@inova.org.
² Genentech, Inc., South San Francisco, CA, USA.

Abstract

Variability in 3-month changes in FVC was examined in 954 patients with IPF (n=3966 observations) from phase 3 trials; concurrent 3-month decline in the FVC and 6MWD (n=1321 observations) predicted further decline in FVC over the subsequent 3 months http://bit.ly/2GfBKW3

Publication types

Letter
Research Support, Non-U.S. Gov't

MeSH terms

Disease Progression*
Humans
Idiopathic Pulmonary Fibrosis / physiopathology*
Predictive Value of Tests
Vital Capacity*
Walk Test*