Photocontrol of Metabotropic Glutamate Receptors: When One Agonist Is Not Enough, Make It Two

Laetitia Mony; Pierre Paoletti

doi:10.1016/j.neuron.2020.01.013

Photocontrol of Metabotropic Glutamate Receptors: When One Agonist Is Not Enough, Make It Two

Neuron. 2020 Feb 5;105(3):395-397. doi: 10.1016/j.neuron.2020.01.013.

Authors

Laetitia Mony¹, Pierre Paoletti²

Affiliations

¹ Institut de Biologie de l'Ecole Normale Supérieure (IBENS), Ecole Normale Supérieure, Institut National de la Santé et de la Recherche Médicale (INSERM), Centre National de la Recherche Scientifique (CNRS), Université PSL, Paris, France. Electronic address: laetitia.mony@ens.fr.
² Institut de Biologie de l'Ecole Normale Supérieure (IBENS), Ecole Normale Supérieure, Institut National de la Santé et de la Recherche Médicale (INSERM), Centre National de la Recherche Scientifique (CNRS), Université PSL, Paris, France. Electronic address: pierre.paoletti@ens.fr.

PMID: 32027826
DOI: 10.1016/j.neuron.2020.01.013

Abstract

A current major challenge lies in controlling molecularly defined brain receptor and channel populations to investigate their function in vivo. In this issue of Neuron, Acosta-Ruiz et al. (2020) developed a highly versatile molecular toolkit to efficiently manipulate specific metabotropic glutamate receptor subtypes in brain circuits with light.

Publication types

Comment

MeSH terms

Brain
Ligands
Neurons
Receptors, Metabotropic Glutamate*

Substances

Ligands
Receptors, Metabotropic Glutamate