Alcohol Makes Its Epigenetic Marks

Subhash C Pandey; John Peyton Bohnsack

doi:10.1016/j.cmet.2020.01.008

Alcohol Makes Its Epigenetic Marks

Cell Metab. 2020 Feb 4;31(2):213-214. doi: 10.1016/j.cmet.2020.01.008.

Authors

Subhash C Pandey¹, John Peyton Bohnsack²

Affiliations

¹ Center for Alcohol Research in Epigenetics, Department of Psychiatry, University of Illinois at Chicago, Chicago, IL 60612, USA; Jesse Brown VA Medical Center, Chicago, IL 60612, USA. Electronic address: scpandey@uic.edu.
² Center for Alcohol Research in Epigenetics, Department of Psychiatry, University of Illinois at Chicago, Chicago, IL 60612, USA.

Abstract

The toxic effects of alcohol consumption are dependent upon its metabolism in the liver to downstream metabolites: acetaldehyde, acetate, and acetyl-CoA. Recently, in Nature, Mews et al. (2019) have discovered that acetyl-CoA derived from alcohol plays an important epigenetic role in regulating ethanol's effects on the brain through histone acetylation.

Published by Elsevier Inc.

Publication types

Research Support, N.I.H., Extramural
Research Support, U.S. Gov't, Non-P.H.S.
Comment

MeSH terms

Acetyl Coenzyme A
Acetylation
Brain
Epigenesis, Genetic
Ethanol*
Histones*

Substances

Histones
Ethanol
Acetyl Coenzyme A

Abstract

Publication types

MeSH terms

Substances

Grants and funding