2 Nephrology Division, the Third Affiliated Hospital of Sun Yat-sen University, Guangzhou, Guangdong 510630, China.
3 Key Lab of Green Chem & Tech of MOE, and College of Chemistry, Sichuan University, 29 Wangjiang Road, Chengdu, Sichuan 610064, China.
4 Biliary Surgical Department of West China Hospital, Sichuan University, Chengdu, Sichuan 610064, China. zhourongxing@163.com.
5 Analytical & Testing Center, Sichuan University, 29 Wangjiang Road, Chengdu, Sichuan 610064, China. junbochen@scu.edu.cn and Key Lab of Green Chem & Tech of MOE, and College of Chemistry, Sichuan University, 29 Wangjiang Road, Chengdu, Sichuan 610064, China.
A DNAzyme-powered micromachine with anti-interfering properties and displaying resistance to being inhibited by biological matrices was built. This micromachine was able to respond to a specific target in high-concentration serum or whole blood.