Progress in understanding the relationship between long noncoding RNA and endometriosis

Wenying Yan; Hongmei Hu; Biao Tang

doi:10.1016/j.eurox.2019.100067

Progress in understanding the relationship between long noncoding RNA and endometriosis

Eur J Obstet Gynecol Reprod Biol X. 2019 Jun 15:5:100067. doi: 10.1016/j.eurox.2019.100067. eCollection 2020 Jan.

Authors

Wenying Yan¹, Hongmei Hu², Biao Tang²

Affiliations

¹ Department of Gynecology, Wangjiang Hospital, Sichuan University, China, No. 24, South Section of First Ring Road, Chengdu City, Sichuan Province, China.
² Department of Gynecology, Sichuan Maternal and Child Health Hospital, No. 290 Shayan West Second Street, Jinyang Road, Chengdu City, Sichuan Province, China.

Abstract

Endometriosis is a common gynecological disease. However, the etiology of endometriosis is still unclear, and current theories cannot fully elaborate its specific pathogenesis. Recently, some research has suggested that the occurrence and development of endometriosis may be related to genetics. Long-chain non-coding RNA (lncRNAs) is a kind of non-protein-coding RNA molecule with a length of 200-100,000 bp. With complex biological functions, lncRNAs play an important role in the normal development of individuals and the progression of various diseases, and lncRNAs have become an important field of medical research in recent years. This paper mainly illustrates the research progress on lncRNAs as they relate to endometriosis. We also provide some ideas for exploring the pathogenesis of endometriosis.

Keywords: CDK6, cyclin dependent kinase 6; EMs, Endometriosis; Early diagnosis; Endometriosis; HIF-1α, Hypoxia inducible factor-1alpha; Igf1r, insulin-like growth factor-1 receptor; Igf2, insulin-like growth factor 2; NATs, natural antisense transcripts; Non-coding RNA; SRA, Steroid receptor RNA activator; SRAP, steroid receptor activator protein; lncRNAs; lncRNAs, long non-coding RNAs; ncRNAs, non-coding RNAs; piRNAs, PIWI-interacting RNAs; siRNAs, short inhibitory RNAs; snRNAs, small nuclear RNAs.

Publication types

Review