Minimal spatial heterogeneity in chronic lymphocytic leukemia at diagnosis

Ferran Nadeu; Romina Royo; Francesco Maura; Kevin J Dawson; Ana Dueso-Barroso; Marta Aymerich; Magda Pinyol; Sílvia Beà; Armando López-Guillermo; Julio Delgado; Xose S Puente; Elías Campo

doi:10.1038/s41375-020-0730-3

Minimal spatial heterogeneity in chronic lymphocytic leukemia at diagnosis

Leukemia. 2020 Jul;34(7):1929-1933. doi: 10.1038/s41375-020-0730-3. Epub 2020 Feb 4.

Authors

Ferran Nadeu^{1

2}, Romina Royo³, Francesco Maura^{4

5}, Kevin J Dawson⁵, Ana Dueso-Barroso³, Marta Aymerich^{1

2

6}, Magda Pinyol^{2

7}, Sílvia Beà^{1

2}, Armando López-Guillermo^{1

2

6

8}, Julio Delgado^{1

2

6}, Xose S Puente⁹, Elías Campo^{10

11

12

13}

Affiliations

¹ Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Barcelona, Spain.
² Centro de Investigación Biomédica en Red de Cáncer (CIBERONC), Madrid, Spain.
³ Barcelona Supercomputing Center (BSC), Barcelona, Spain.
⁴ Myeloma Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
⁵ Wellcome Trust Sanger Institute, Hinxton, Cambridgeshire, UK.
⁶ Hospital Clínic of Barcelona, Barcelona, Spain.
⁷ Unitat de Genòmica, IDIBAPS, Barcelona, Spain.
⁸ Universitat de Barcelona, Barcelona, Spain.
⁹ Departamento de Bioquímica y Biología Molecular, Instituto Universitario de Oncología, Universidad de Oviedo, Oviedo, Spain.
¹⁰ Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Barcelona, Spain. ecampo@clinic.cat.
¹¹ Centro de Investigación Biomédica en Red de Cáncer (CIBERONC), Madrid, Spain. ecampo@clinic.cat.
¹² Hospital Clínic of Barcelona, Barcelona, Spain. ecampo@clinic.cat.
¹³ Universitat de Barcelona, Barcelona, Spain. ecampo@clinic.cat.

PMID: 32020046
DOI: 10.1038/s41375-020-0730-3

No abstract available

Publication types

Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't

MeSH terms

Aged
Aged, 80 and over
Bone Marrow / metabolism
Bone Marrow / pathology*
Cohort Studies
Exome Sequencing
Female
Follow-Up Studies
Genetic Heterogeneity*
Humans
Leukemia, Lymphocytic, Chronic, B-Cell / classification*
Leukemia, Lymphocytic, Chronic, B-Cell / genetics
Leukemia, Lymphocytic, Chronic, B-Cell / pathology*
Leukocytes, Mononuclear / metabolism
Leukocytes, Mononuclear / pathology*
Lymph Nodes / metabolism
Lymph Nodes / pathology*
Male
Middle Aged
Prognosis
Spatial Analysis
Whole Genome Sequencing