The emerging role of skeletal muscle mitochondrial dynamics in exercise and ageing

Rafael A Casuso; Jesús R Huertas

doi:10.1016/j.arr.2020.101025

The emerging role of skeletal muscle mitochondrial dynamics in exercise and ageing

Ageing Res Rev. 2020 Mar:58:101025. doi: 10.1016/j.arr.2020.101025. Epub 2020 Feb 1.

Authors

Rafael A Casuso¹, Jesús R Huertas²

Affiliations

¹ Institute of Nutrition and Food Technology, Biomedical Research Centre, Department of Physiology, Faculty of Sport Sciences, University of Granada, Avda del conocimiento s/n. 18016 Armilla, Granada, Spain. Electronic address: casusopt@gmail.com.
² Institute of Nutrition and Food Technology, Biomedical Research Centre, Department of Physiology, Faculty of Sport Sciences, University of Granada, Avda del conocimiento s/n. 18016 Armilla, Granada, Spain.

PMID: 32018055
DOI: 10.1016/j.arr.2020.101025

Abstract

Mitochondria are the hub for energy production within living cells. They can undergo morphological changes in response to nutrient availability and cellular stress. Here, we review how exercise chronically and acutely affects mitochondrial dynamics. Moreover, we discuss whether mitochondrial dysfunction observed in elderly subjects is due to the ageing process per se or due to the associated sedentary state. Finally, we study how endurance exercise can improve mitochondrial dynamics in older subjects, thereby improving their overall health and likely limiting muscle waste.

Keywords: DRP1; Endurance training; MFN1; MFN2; Muscle mass; OPA1.

Publication types

Review

MeSH terms

Aged
Aging*
Exercise*
Humans
Mitochondria, Muscle*
Mitochondrial Dynamics*
Mitochondrial Proteins
Muscle, Skeletal

Substances

Mitochondrial Proteins