Cell Biology: Function Guides Form of Auditory Sensory Cells

Jamis McGrath; Benjamin J Perrin

doi:10.1016/j.cub.2019.12.039

Cell Biology: Function Guides Form of Auditory Sensory Cells

Curr Biol. 2020 Feb 3;30(3):R128-R130. doi: 10.1016/j.cub.2019.12.039.

Authors

Jamis McGrath¹, Benjamin J Perrin²

Affiliations

¹ Department of Biology, Indiana University-Purdue University Indianapolis, Indianapolis, IN 46202, USA.
² Department of Biology, Indiana University-Purdue University Indianapolis, Indianapolis, IN 46202, USA. Electronic address: bperrin@iupui.edu.

PMID: 32017884
DOI: 10.1016/j.cub.2019.12.039

Abstract

Mechanosensory bundles on auditory sensory cells are composed of stereocilia that grow in rows of decreasing height. This pattern depends on the specification of the eventual tallest row, then the assignment of distinct molecular identities to the shorter rows. Mechanotransduction refines and maintains row identity, thus instructing the form of the bundle.

Publication types

Research Support, N.I.H., Extramural
Comment

MeSH terms

Cilia
Hair Cells, Auditory*
Hair Cells, Auditory, Inner
Mechanotransduction, Cellular
Stereocilia*

Grants and funding

R01 DC015495/DC/NIDCD NIH HHS/United States